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Indiana Health Coverage and Cholesterol

Indiana health coverage news is available through Chambers Roper and is your place for information. Researchers at the University of Leicester and the University of California in Los Angeles have filed for patents on two drugs intended to battle cholesterol.

LDL, or bad cholesterol, has been linked to numerous health concerns, including heart disease, clogged arteries or “hardening” of the arteries, and strokes. However, researchers working in tandem from these 2 universities have identified an enzyme that regulates the production of LDL cholesterol.

The human body produces a receptor that binds with LDL cholesterol to remove it from the body, thereby regulating its presence in the arteries. This enzyme that has been discovered triggers the amount of receptors available to bind with the LDL cholesterol. The enzyme, referred to as IDOL, can possibly be targeted with drugs, causing it to trigger more production of receptors, binding more LDL cholesterol and removing it from the body. LDL receptors that bind with the LDL cholesterol are usually generated in the liver.

The head of the study, Prof. John Schwabe, says that the studies now focus on the understanding of IDOL’s activity and its effects on LDL. It seems that, IDOL works with an E2 ligase called UBE2D to produce the LDL receptor.

The hope is that a drug that can target IDOL may be used along with statins, improving the function and efficacy of both drugs.

Cholesterol is found within each cell in the human body. In fact, cholesterol is what makes cell membranes stable so that it is less permeable to invasion from foreign molecules. It also provides energy on which the cells function, and from which they make proteins. It is also vital to the body’s formation of vitamin D. As the body is exposed to sunlight, cholesterol plays an important part in enabling the body to convert the ultraviolet B into vitamin D. Without cholesterol, the body can’t function properly. Since cholesterol is insoluble, it must have a carrier to circulate through the body. This is accomplished with lipoproteins in the form of high density, or HDL, and low density, or LDL. According to information provided by Indiana health coverage, the LDL tends to build up on the walls of arteries, leading to heart disease. HDL actually protects the heart from disease. In addition, the plaque that builds up in arteries can break loose and travel to the brain, causing strokes.

Cholesterol also aids in hormone production. Cholesterol, stored in the ovaries, testes, and adrenal glands, becomes steroids in the body. These steroid hormones have many different functions in the body, including sex, bone health, weight, digestion, and mental well being. In addition, the liver uses cholesterol to create bile, necessary for proper digestion. When our bodies don’t have enough bile, they can’t digest fats and other foods. Undigested fats go into the bloodstream, causing more problems in the way of artery blockage. The fats can also cause heart disease and heart attacks.

Depending on your Indiana health coverage, statin drugs may be prescribed by a physician.

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